Abstract

Publisher Summary This chapter reviews oxygen poisoning and X-irradiation. Exposure to unphysiologically high tensions of oxygen causes irreversible damage to living matter. The problem of oxygen toxicity is important in clinical medicine and in deep-sea diving. A consideration of various isolated reports leads to the hypothesis that oxygen poisoning and the primary action of X-irradiation have a common basis of action: possibly the formation of the oxidizing free radicals OH, and O2H, and H2O2. The evidence of a protective effect of coenzyme A against X-rays and against oxygen toxicity in experiments is incomplete and needs further studies. The chapter presents a table reporting the effect of X-rays and protective agents on oxygen poisoning in mice.

Keywords

OxygenMechanism (biology)IrradiationChemistryPhysicsNuclear physics

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Publication Info

Year
1954
Type
article
Volume
119
Issue
3097
Pages
623-626
Citations
950
Access
Closed

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R. Gerschman, Daniel L. Gilbert, Sylvanus W. Nye et al. (1954). Oxygen Poisoning and X-irradiation: A Mechanism in Common. Science , 119 (3097) , 623-626. https://doi.org/10.1126/science.119.3097.623

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DOI
10.1126/science.119.3097.623