Abstract
As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of the critical and complex roles played by p53 is progressing rapidly, new findings continue to pose new paradoxes. Here we present some of these recent advances in p53 research and discuss how they either shed light on or add to the complexities of p53. Therefore, we only briefly summarize some of the key developments leading to our current state of knowledge. For further information, the reader is referred to several excellent reviews that have focused on p53 research (see Donehower and Bradley 1993; Levine 1993; Greenblatt et al. 1994; Oren 1994; Prives 1994; Kinzler and Vogelstein 1996).
Keywords
BiologyComputational biologyEvolutionary biologyGenetics
MeSH Terms
AnimalsApoptosisBase SequenceCell DifferentiationGenesp53HumansMolecular Sequence DataNeoplasmsSignal TransductionTranscriptionGeneticTumor Suppressor Protein p53
Affiliated Institutions
Related Publications
The complexity of p53 modulation: emerging patterns from divergent signals
Functional inactivation of p53 by gene mutation and deletion, protein degradation, or viral oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and enviro...
Publication Info
- Year
- 1996
- Type
- review
- Volume
- 10
- Issue
- 9
- Pages
- 1054-1072
- Citations
- 2347
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2347
OpenAlex
108
Influential
1868
CrossRef
Cite This
L J Ko,
Carol Prives
(1996).
p53: puzzle and paradigm..
Genes & Development
, 10
(9)
, 1054-1072.
https://doi.org/10.1101/gad.10.9.1054
Identifiers
- DOI
- 10.1101/gad.10.9.1054
- PMID
- 8654922