PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

Abstract

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

Keywords

Immunoglobulin superfamilyImmunoglobulin domainImmunoglobulin geneAntibodyCell adhesion moleculeBiologyGlycoproteinCell adhesionMolecular biologyGeneCell biologyMolecular cloningclone (Java method)CellPeptide sequenceGenetics

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Publication Info

Year: 1990
Type: article
Volume: 247
Issue: 4947
Pages: 1219-1222
Citations: 947
Access: Closed

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APA Style

                            
                                
                                    Peter J. Newman, 
                                
                                    Michael C. Berndt, 
                                
                                    Jack Gorski
                                
                                et al.
                            
                            (1990). 
                            PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily. 
                            Science
                            , 247
                            (4947)
                            , 1219-1222.
                            https://doi.org/10.1126/science.1690453
                        

Identifiers

DOI: 10.1126/science.1690453