Abstract

Mice harboring mutations in the obese ( ob ) and diabetes ( db ) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob , and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db , rat fatty (a homolog of db ), and the gene encoding the OB-R are the same gene.

Keywords

LeptinLeptin receptorPhenotypeGeneBiologyReceptorGeneticsMutationCloning (programming)Diabetes mellitusEndocrinologyInternal medicineObesityMedicine

MeSH Terms

AnimalsBase SequenceBlottingSouthernCarrier ProteinsChromosome MappingCloningMolecularDNA Mutational AnalysisDiabetes MellitusGenetic MarkersLeptinMiceMiceInbred C57BLMiceInbred StrainsMolecular Sequence DataObesityPhenotypePolymerase Chain ReactionProteinsRatsRatsInbred StrainsReceptorsCell SurfaceReceptorsCytokineReceptorsLeptin

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Publication Info

Year
1996
Type
article
Volume
271
Issue
5251
Pages
994-996
Citations
1070
Access
Closed

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Cite This

Streamson C. Chua, Wendy K. Chung, X. Sharon Wu-Peng et al. (1996). Phenotypes of Mouse <i>diabetes</i> and Rat <i>fatty</i> Due to Mutations in the OB (Leptin) Receptor. Science , 271 (5251) , 994-996. https://doi.org/10.1126/science.271.5251.994

Identifiers

DOI
10.1126/science.271.5251.994
PMID
8584938

Data Quality

Data completeness: 81%