Photoinduced Cobalt‐Catalyzed Reductive Coupling of Aryl Bromides and 1,4‐Dihydropyridines

Abstract

ABSTRACT The construction of C(sp 2 )─C(sp 3 ) bond represents a fundamental yet challenging transformation in organic synthesis. Here, we reported a photoinduced cobalt‐catalyzed reductive coupling reaction that efficiently constructs C(sp 2 )─C(sp 3 ) bond between aryl bromides and 1,4‐dihydropyridines. This protocol exhibits good functional group compatibility and broad substrate scope (31 examples, up to 93% yield) under mild reaction conditions. Mechanistic studies reveal that the alkylzinc reagents may be generated via photoinduced single‐electron reduction, expanding the synthetic box for organozinc compound preparation.

Affiliated Institutions

• Wuhan Institute of Technology CN
• Chinese Academy of Sciences CN
• Central China Normal University CN
• Henan Normal University CN
• Lanzhou Institute of Chemical Physics CN

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