Abstract

PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.

Keywords

Protein Data Bank (RCSB PDB)Computer scienceMutationProtein Data BankGraphical user interfaceAnnotationPoint mutationComputational biologyBioinformaticsArtificial intelligenceGeneticsProtein structureBiologyProgramming languageBiochemistryGene

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Publication Info

Year
2005
Type
article
Volume
21
Issue
14
Pages
3176-3178
Citations
500
Access
Closed

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Carles Ferrer‐Costa, Josep Lluis Gelpí, L. Zamakola et al. (2005). PMUT: a web-based tool for the annotation of pathological mutations on proteins. Computer applications in the biosciences , 21 (14) , 3176-3178. https://doi.org/10.1093/bioinformatics/bti486

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DOI
10.1093/bioinformatics/bti486