Abstract
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
Keywords
Polycomb-group proteinsRepressorPsychological repressionMulticellular organismHistoneTranscription (linguistics)Non-histone proteinBiologyTranscriptional regulationTranscription factorDNA-binding proteinGeneRegulation of gene expressionGeneticsCell biologyGene expression
MeSH Terms
AnimalsHistonesHumansPolycomb-Group ProteinsRepressor ProteinsResponse ElementsTranscription FactorsTranscriptionGenetic
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Publication Info
- Year
- 2010
- Type
- review
- Volume
- 35
- Issue
- 6
- Pages
- 323-332
- Citations
- 375
- Access
- Closed
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Cite This
Lluís Morey,
Kristian Helin
(2010).
Polycomb group protein-mediated repression of transcription.
Trends in Biochemical Sciences
, 35
(6)
, 323-332.
https://doi.org/10.1016/j.tibs.2010.02.009
Identifiers
- DOI
- 10.1016/j.tibs.2010.02.009
- PMID
- 20346678