Population stratification and spurious allelic association

Keywords

Population stratificationSpurious relationshipGenetic associationSingle-nucleotide polymorphismPopulationGenotypingGenome-wide association studyBiologyGeneticsCohortGenotypeComputer scienceMedicineStatisticsEnvironmental healthMachine learningMathematics

Affiliated Institutions

Related Publications

Discerning the Ancestry of European Americans in Genetic Association Studies

Alkes L. Price , Johannah L. Butler , Hon‐Cheong So +17 more

European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the...

2008 PLoS Genetics 318 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

The Genotype-Tissue Expression (GTEx) project.

John T. Lonsdale , Jeffrey Thomas , Mike Salvatore +97 more

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

2013 PubMed 9436 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Eleftheria Zeggini , Michael N. Weedon , Cecilia M. Lindgren +23 more

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 populatio...

2007 Science 2195 citations

Publication Info

Year: 2003
Type: review
Volume: 361
Issue: 9357
Pages: 598-604
Citations: 1213
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Population stratification and spurious allelic association

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1213

OpenAlex

Cite This

APA Style

                            
                                    Lon R. Cardon, 
                                
                                    Lyle J. Palmer
                                
                            (2003). 
                            Population stratification and spurious allelic association. 
                            The Lancet
                            , 361
                            (9357)
                            , 598-604.
                            https://doi.org/10.1016/s0140-6736(03)12520-2

Identifiers

DOI: 10.1016/s0140-6736(03)12520-2