Prediction of the Risk of Bleeding During Anticoagulant Treatment for Venous Thromboembolism

Philomeen Kuijer; Barbara A. Hutten; Martin H. Prins; Harry R. Büller

doi:10.1001/archinte.159.5.457

Abstract

With the use of 3 easily obtainable, clinical variables in a prediction model, it is possible to identify a subgroup of patients at the start of anticoagulant therapy who have a high risk of developing hemorrhagic complications. Further studies should address whether additional measures to prevent bleeding decrease the bleeding incidence without compromising efficacy.

Keywords

MedicineConfidence intervalAnticoagulantFramingham Risk ScoreCohortReceiver operating characteristicAnticoagulant therapyOdds ratioInternal medicineRisk assessmentSurgery

MeSH Terms

AnticoagulantsFemaleHemorrhageHumansIncidenceMaleMiddle AgedModelsStatisticalOdds RatioPredictive Value of TestsRiskRisk FactorsThromboembolism

Affiliated Institutions

University of Amsterdam NL

Related Publications

Low-Dose Aspirin for Prevention of Stroke in Low-Risk Patients With Atrial Fibrillation

Hiroshi Sato , Kinji Ishikawa , Akira Kitabatake +15 more

Background and Purpose— Although the efficacy of anticoagulant therapy for primary prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) has been establis...

2005 Stroke 280 citations

A Method to Determine the Optimal Intensity of Oral Anticoagulant Therapy

F.R. Rosendaal , Suzanne C. Cannegieter , F.J.M. van der Meer +1 more

Summary Oral anticoagulant therapy has been shown to be effective for several indications. The optimal intensity of anticoagulation for each indication, however, is largely unkn...

1993 Thrombosis and Haemostasis 2013 citations

Atrial fibrillation and stroke prevention

Gregory Y.H. Lip , Hoong Sern Lim

2007 The Lancet Neurology 235 citations

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

Manesh R. Patel , Kenneth W. Mahaffey , Jyotsna Garg +13 more

In patients with atrial fibrillation, rivaroxaban was noninferior to warfarin for the prevention of stroke or systemic embolism. There was no significant between-group differenc...

2011 New England Journal of Medicine 9184 citations

Oral anticoagulation self-management and management by a specialist anticoagulation clinic: a randomised cross-over comparison

Manon E. Cromheecke , Marcel Levi , L. P. Colly +6 more

2000 The Lancet 290 citations

Publication Info

Year: 1999
Type: article
Volume: 159
Issue: 5
Pages: 457-457
Citations: 416
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Prediction of the Risk of Bleeding During Anticoagulant Treatment for Venous Thromboembolism

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

416

OpenAlex

Influential

311

CrossRef

Cite This

APA Style

                            
                                
                                    Philomeen Kuijer, 
                                
                                    Barbara A. Hutten, 
                                
                                    Martin H. Prins
                                
                                et al.
                            
                            (1999). 
                            Prediction of the Risk of Bleeding During Anticoagulant Treatment for Venous Thromboembolism. 
                            Archives of Internal Medicine
                            , 159
                            (5)
                            , 457-457.
                            https://doi.org/10.1001/archinte.159.5.457
                        

Identifiers

DOI: 10.1001/archinte.159.5.457
PMID: 10074953

Data Quality

Data completeness: 86%