Abstract

Loading of HAuCl4 in poly(amido amine) G4 dendrimers having poly(ethylene glycol) (PEG) grafts at all chain ends and subsequent reduction with NaBH4 yielded PEG-modified dendrimers encapsulating gold nanoparticles (Au NPs) of ca. 2 nm diameter. The Au NPs held in the dendrimers were stable in aqueous solutions and dissolved readily, even after freeze-drying. Despite their small particle size, the heat-generating ability of Au NPs held in the dendrimer was comparable to that of widely used Au NPs with ca. 11 nm diameter under visible light irradiation. The observed excellent colloidal stability, high heat-generating ability and their biocompatible surface confirm that the PEG-modified dendrimers encapsulating Au NPs are a promising tool for photothermal therapy and imaging.

Keywords

DendrimerEthylene glycolColloidal goldPEG ratioNanoparticlePolymer chemistryAmine gas treatingAqueous solutionMaterials scienceSurface modificationChemistryPhotothermal therapyChemical engineeringColloidNanotechnologyOrganic chemistryPhysical chemistry

Affiliated Institutions

Related Publications

Publication Info

Year
2007
Type
article
Volume
23
Issue
10
Pages
5243-5246
Citations
123
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

123
OpenAlex
1
Influential
108
CrossRef

Cite This

Yasuhiro Haba, Chie Kojima, Atsushi Harada et al. (2007). Preparation of Poly(ethylene glycol)-Modified Poly(amido amine) Dendrimers Encapsulating Gold Nanoparticles and Their Heat-Generating Ability. Langmuir , 23 (10) , 5243-5246. https://doi.org/10.1021/la0700826

Identifiers

DOI
10.1021/la0700826
PMID
17419657

Data Quality

Data completeness: 77%