Abstract

Sera from 133 cervical cancer patients and 154 healthy women (controls) from Spain and Colombia were tested in IgG-specific ELISAs for the presence of antibodies against seven peptides derived from five open-reading frames of human papillomavirus (HPV) type 16. Three of the peptides corresponded to overlapping regions of the N-terminal half of E7 protein; the other peptides corresponded to selected regions of E2, E4, L1, and L2 proteins. The prevalence of antibodies against E2 and E7 peptides was significantly different between patients and controls. The most marked differences were for E7 peptides. HPV DNA polymerase chain reaction diagnoses of cervical scrapes were available; these were correlated with serologic findings. In HPV-16 DNA-positive patients, E7 antibodies were more broadly and more strongly reactive than in other patient groups.

Keywords

AntibodySerologyPolymerase chain reactionHuman papillomavirusVirologyImmunologyCervical cancerBiologyCancerDNAMedicineMolecular biologyInternal medicineGeneticsGene

MeSH Terms

Age FactorsAmino Acid SequenceAntibodiesViralCase-Control StudiesColombiaDNAViralFemaleHumansMolecular Sequence DataOncogene ProteinsViralPapillomaviridaePapillomavirus InfectionsPeptidesPolymerase Chain ReactionSpainTumor Virus InfectionsUterine Cervical Neoplasms

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Publication Info

Year
1994
Type
article
Volume
170
Issue
6
Pages
1424-1431
Citations
27
Access
Closed

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Cite This

E. Hamskova, Jan Novák, Vanda Hofmannová et al. (1994). Presence Of Antibodies To Seven Human Papillomavirus Type 16-Derived. The Journal of Infectious Diseases , 170 (6) , 1424-1431. https://doi.org/10.1093/infdis/170.6.1424

Identifiers

DOI
10.1093/infdis/170.6.1424
PMID
7995981

Data Quality

Data completeness: 81%