Abstract
We performed a retrospective review of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) examination to determine the prevalence of thyroid FDG-PET incidentaloma in a patient group evaluated for metastasis of cancer and in a group of healthy subjects who underwent voluntary cancer screening. We also evaluated the risk of malignancy in focal thyroid FDG-PET incidentaloma and its association with standard uptake values (SUVs) (maximum and greater than 0.75 threshold). A total of 1330 subjects underwent FDG-PET for metastasis evaluation (n = 999) and cancer screening (n = 331). Twenty-nine of 1330 subjects (2.2%) showed focal (n = 21) or diffuse (n = 8) thyroid FDG-PET incidentaloma. There was no significant difference in the prevalence of thyroid FDG-PET incidentaloma between the two groups (19 of 999 vs. 10 of 331; P > 0.05). Four of 15 focal incidentalomas (26.7%) whose histological diagnoses were available showed papillary thyroid cancer. The maximum SUV (16.5 +/- 4.70) and greater than 0.75 threshold SUV (14.2 +/- 5.3) of malignant lesions were significantly higher than those of benign tumors (6.5 +/- 3.8 and 4.9 +/- 3.0; P < 0.05). In conclusion, thyroid FDG-PET incidentaloma has prevalence of 2.2%, and its prevalence was not different according to the purpose of the FDG-PET. The focal thyroid FDG-PET incidentaloma carries a high risk of malignancy, especially in cases with high SUVs. Therefore, focal thyroid FDG-PET incidentaloma with high SUVs warrants a pathological diagnostic procedure if it changes a patient's treatment plan or prognosis.
Keywords
IncidentalomaMedicineMalignancyPositron emission tomographyThyroid cancerFluorodeoxyglucoseCancerRadiologyThyroidMetastasisNuclear medicineInternal medicine
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Publication Info
- Year
- 2003
- Type
- article
- Volume
- 88
- Issue
- 9
- Pages
- 4100-4104
- Citations
- 287
- Access
- Closed
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Cite This
Keon Wook Kang,
Seok-Ki Kim,
Han‐Sung Kang
et al.
(2003).
Prevalence and Risk of Cancer of Focal Thyroid Incidentaloma Identified by<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography for Metastasis Evaluation and Cancer Screening in Healthy Subjects.
The Journal of Clinical Endocrinology & Metabolism
, 88
(9)
, 4100-4104.
https://doi.org/10.1210/jc.2003-030465
Identifiers
- DOI
- 10.1210/jc.2003-030465