Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

A. Tonkin , Philip E Alyward , David Colquhoun , A. Tonkin , Philip E Alyward , David Colquhoun , Paul Glasziou , Philip A. Harris , David Hunt , Anthony Keech , Stephen MacMahon , P. D. Magnus , David W. Newel , Paul J. Nestel , N. Sharpe , Jonathan W Shaw , R. J. Simes , P. Thompson , Andrew Thompson , Malcolm West , Harvey D. White , S. Simes , Wendy Hague , Sue Caleo , Jane Hall , Andrew Martin , Sarah Mulray , Philip J. Barter , Lawrence J. Beilin , Rory Collins , John J. McNeil , Petra Meier , H. Willimott , D A Smithers , Patricia Wallace , Jannah Baker , Matthew Hobbs , David Sullivan , Neil E. Anderson , Graeme J. Hankey , J D Watson , M. Arulchelvam , S. Chup , John Daly , Joseph Hanna , A. Leach , Matthew M.Y. Lee , J. Loughhead , H. Lundie-Jenkin , Jill Morrison , S. Netting , Ai‐Lan Nguyen , H Pater , Richard Philip , Gian Domenico Pinna , D. Rattos , Susan Ryerson , В П Сажин , R. C. Walsh , A. Claque , M. Mackie , Julie Yallop , Kristina Boss , M. Shepard , John K. Leach , Milena Gandy , J. Joughin , J. Seabrook , R Abraham , Jerilyn K. Allen , Frank S. Bates , I. Beinart , Ernest S. Breed , David Brown , N. Bunyan , Dennis Calvert , Timothy Campbell , Deanne Condon‐Paoloni , Baqiyyah Conway , Lucy A. Coupland , Joseph P. Crowe , N. Cunio , Bruce N. Cuthbert , Nigel J. Cuthbert , Sean Darcy , Patricia M. Davidson , Brian Dwyer , J. England , Charlotte Friend , Gregory Fulcher , Shannon Grant , Kevin J. Hellestrand , Maina Kava , Leonard Kritharides , David McGill , Hamish D. McKee , Anna McLean , M. A. Neaverson , G. Nelson , Michael F. O‘Neill , Chiaki Onuma , Fiona O’Reilly
1998 New England Journal of Medicine 5,274 citations

Abstract

Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.

Keywords

PravastatinMedicineMyocardial infarctionInternal medicineRelative riskCardiologyAnginaPlaceboConfidence intervalUnstable anginaStroke (engine)Incidence (geometry)Cholesterol

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Publication Info

Year
1998
Type
article
Volume
339
Issue
19
Pages
1349-1357
Citations
5274
Access
Closed

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A. Tonkin, Philip E Alyward, David Colquhoun et al. (1998). Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels. New England Journal of Medicine , 339 (19) , 1349-1357. https://doi.org/10.1056/nejm199811053391902

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DOI
10.1056/nejm199811053391902