Abstract

Long-term nonsteroidal anti-inflammatory drug (NSAID) use was protective against Alzheimer disease. Findings were clearest for ibuprofen. A beta (1-42)-suppressing NSAIDs did not differ from others.

Keywords

MedicineNonsteroidalIbuprofenInternal medicineOdds ratioObservational studyConditional logistic regressionAspirinVeterans AffairsLogistic regressionDiseasePopulationDrugPharmacology

MeSH Terms

Age FactorsAgedAlzheimer DiseaseAmyloid beta-PeptidesAnti-Inflammatory AgentsNon-SteroidalBrainCase-Control StudiesDrug Administration ScheduleEncephalitisFemaleHumansIbuprofenMaleMiddle AgedNeuroprotective AgentsPeptide FragmentsRacial GroupsSex DistributionTimeTreatment Outcome

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Publication Info

Year
2008
Type
article
Volume
70
Issue
19
Pages
1672-1677
Citations
505
Access
Closed

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Cite This

Steven C. Vlad, Donald R. Miller, Neil W. Kowall et al. (2008). Protective effects of NSAIDs on the development of Alzheimer disease. Neurology , 70 (19) , 1672-1677. https://doi.org/10.1212/01.wnl.0000311269.57716.63

Identifiers

DOI
10.1212/01.wnl.0000311269.57716.63
PMID
18458226
PMCID
PMC2758242

Data Quality

Data completeness: 86%