Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway

Meng Zhang; Wei Liu; Yunhui Liu; Qiuyu Cheng; Xiaolei Zhang; Na Qian; Junying Qi; Tao Chen; Y. Yu

doi:10.1007/s11033-025-11336-y

Abstract

Although the absence of macroscopic intestinal lesions, PPI directly enhances intestinal epithelial paracellular permeability by decreasing the expression of the tight junction protein occludin, mediated by the p38-MAPK/NF-κB signaling pathway. These findings highlight that the potential and insidious side effects of PPI on the intestinal epithelial barrier warrant increased attention and caution from clinicians when prescribing PPIs for various gastrointestinal diseases.

Keywords

Intestinal epithelial paracellular permeabilityProton pump inhibitorSignaling pathwaysTight junction proteins

MeSH Terms

AnimalsHumansIntestinal MucosaMiceMalep38 Mitogen-Activated Protein KinasesNF-kappa BSignal TransductionCaco-2 CellsProton Pump InhibitorsMiceInbred C57BLPermeabilityPantoprazoleOccludinJejunumIleumMAP Kinase Signaling SystemEpithelial Cells

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Publication Info

Year: 2025
Type: article
Volume: 53
Issue: 1
Pages: 170-170
Citations: 0
Access: Closed

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APA Style

                            
                                
                                    Meng Zhang, 
                                
                                    Wei Liu, 
                                
                                    Yunhui Liu
                                
                                et al.
                            
                            (2025). 
                            Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway. 
                            Molecular Biology Reports
                            , 53
                            (1)
                            , 170-170.
                            https://doi.org/10.1007/s11033-025-11336-y
                        

Identifiers

DOI: 10.1007/s11033-025-11336-y
PMID: 41369838
PMCID: PMC12696144

Data Quality

Data completeness: 86%