Abstract
The metabolism and excretion of 2-methylaminoethoxycarbonyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2'-carboxylic acid (DDB-S) were investigated in both rats and humans using liquid chromatography/electrospray ion trap mass spectrometry (LC/ESI-MS/MS). In rats, DDB-S was rapidly eliminated from the body after a single 50 mg/kg intravenous injection, with urine being a major excretion route. DDB-S was metabolically stable; approximately 96% of the administered dose was recovered in the form of the parent compound. Nevertheless, 12 metabolites were detected in the urine and feces collected from DDB-S-treated rats. The structural characterizations of the metabolites were elucidated from the MS(n) spectral analysis. Because DDB-S has a pseudo-symmetrical methylenedioxy biphenyl structure, regioselective deuterium-substituted DDB-S (d(5)-DDB-S) was used to assign the metabolic modification. The major metabolic pathways of DDB-S were identified as demethylenation of the methylenedioxy moiety, O-demethylation of the methoxy moiety and glucuronidation. In addition, N-demethylation of the methylaminoethyl group was also detected as a minor reaction.
Keywords
Pluralism (philosophy)Cultural pluralismDemocracyMulticulturalismAssimilation (phonology)SociologyBiculturalismPleaCultural identityPolitical economyCultural assimilationPolitical scienceLawEpistemologyPsychologySocial scienceImmigrationPoliticsNeuroscience of multilingualismNegotiationLinguistics
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Publication Info
- Year
- 1974
- Type
- article
- Volume
- 2
- Issue
- 13
- Pages
- 17-22
- Citations
- 223
- Access
- Closed
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Cite This
John W. Berry
(1974).
Psychological Aspects of Cultural Pluralism: Unity and Identity Reconsidered..
, 2
(13)
, 17-22.
https://doi.org/10.1002/rcm.2549
Identifiers
- DOI
- 10.1002/rcm.2549