Abstract

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1 , were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5′ untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1 . Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.

Keywords

TMPRSS2Prostate cancerFusion geneETS transcription factor familyCancer researchChromoplexyBiologyErgProstateFluorescence in situ hybridizationCancerTranscription factorGenePCA3GeneticsMedicineInternal medicine

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Publication Info

Year
2005
Type
article
Volume
310
Issue
5748
Pages
644-648
Citations
3797
Access
Closed

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Scott A. Tomlins, Daniel R. Rhodes, Sven Perner et al. (2005). Recurrent Fusion of <i>TMPRSS2</i> and ETS Transcription Factor Genes in Prostate Cancer. Science , 310 (5748) , 644-648. https://doi.org/10.1126/science.1117679

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DOI
10.1126/science.1117679