Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

Abstract

Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.

Keywords

MetforminMedicineOverweightType 2 diabetesConfidence intervalDiabetes mellitusPlaceboBody mass indexIncidence (geometry)Weight lossObesityInternal medicineEndocrinology

Affiliated Institutions

George Washington University US

Related Publications

Preventing Type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view

Paul Zimmet , Jonathan E. Shaw , K. G. M. M. Alberti

Abstract The last two decades have seen an explosive increase in the number of people with diabetes globally. There is now an urgent need for strategies to prevent the emerging ...

2003 Diabetic Medicine 206 citations

The Finnish Diabetes Prevention Study (DPS)

Jaana Lindström , Anne Louheranta , Marjo Mannelin +5 more

OBJECTIVE—To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short- and long-term changes in diet and exercise behavior, and 3) effect o...

2003 Diabetes Care 1812 citations

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John Wilding , Rachel L. Batterham , Salvatore Calanna +11 more

In participants with overweight or obesity, 2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body we...

2021 New England Journal of Medicine 3574 citations

Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis

Linda Björkhem‐Bergman , Annika Asplund , Jonatan D. Lindh

Weight gain is a clinically important side effect of antipsychotic drug therapy. The aim of this study was to determine the effect of the antidiabetic drug metformin on antipsyc...

2010 Journal of Psychopharmacology 71 citations

Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association

Tiffany M. Powell‐Wiley , Paul Poirier , Lora E. Burke +8 more

The global obesity epidemic is well established, with increases in obesity prevalence for most countries since the 1980s. Obesity contributes directly to incident cardiovascular...

2021 Circulation 3043 citations

Publication Info

Year: 2002
Type: article
Volume: 346
Issue: 6
Pages: 393-403
Citations: 18639
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

18639

OpenAlex

Cite This

APA Style

                            
                                
                                    William C. Knowler, 
                                
                                    Elizabeth Barrett‐Connor, 
                                
                                    Sarah Fowler
                                
                                et al.
                            
                            (2002). 
                            Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. 
                            New England Journal of Medicine
                            , 346
                            (6)
                            , 393-403.
                            https://doi.org/10.1056/nejmoa012512
                        

Identifiers

DOI: 10.1056/nejmoa012512