Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA

Hans Brandstetter; Vito Türk; H.W. Hoeffken; Doris Grosse; Jörg Stürzebecher; Philip D. Martin; Brian F.P. Edwards; Wolfram Bode

doi:10.1016/0022-2836(92)91054-s

Keywords

BenzamidineThrombinChemistryHydrogen bondTrypsinStereochemistryCrystallographyArginineCrystal structureBinding siteCarboxylateActive siteMoleculeEnzymeBiochemistryAmino acidBiologyOrganic chemistry

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Publication Info

Year: 1992
Type: article
Volume: 226
Issue: 4
Pages: 1085-1099
Citations: 193
Access: Closed

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Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA

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APA Style

                            
                                
                                    Hans Brandstetter, 
                                
                                    Vito Türk, 
                                
                                    H.W. Hoeffken
                                
                                et al.
                            
                            (1992). 
                            Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. 
                            Journal of Molecular Biology
                            , 226
                            (4)
                            , 1085-1099.
                            https://doi.org/10.1016/0022-2836(92)91054-s
                        

Identifiers

DOI: 10.1016/0022-2836(92)91054-s

Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA

Keywords

Affiliated Institutions

Related Publications

A Solid Phase Synthetic Study of the Active Site Region of Staphylococcal Nuclease-T'

Can the Clusters Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>(OOCR)<sub>12</sub> and [Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>(OOCR)<sub>12</sub>]<sub>2</sub> Be Converted into Each Other?

Mapping Out the Molecular Interplay in Monohalobenzene Inclusion Complexes of<i>p</i>-H-calix[5]arene Using Hirshfeld Surfaces

Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate

A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on p<i>K</i><sub>a</sub> and log <i>D</i> Values

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Cite This

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