Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types

Abstract

Taken together, these findings indicate that reprogramming of 3'UTRs by APA, which result from regulation of both general polyadenylation activity and cell type-specific factors and can reset post-transcriptional gene regulatory programs in the cell, is an integral part of iPS cell generation, and the APA pattern can be a good biomarker for cell type and state, useful for sample classification. The results also suggest that perturbation of the mRNA polyadenylation machinery or RNA processing activity may facilitate generation of iPS cells.

Keywords

ReprogrammingPolyadenylationInduced pluripotent stem cellBiologySomatic cellEmbryonic stem cellThree prime untranslated regionUntranslated regionCell biologyStem cellCell typeCellular differentiationmicroRNAGene expressionGeneCellGeneticsRNA

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Publication Info

Year: 2009
Type: article
Volume: 4
Issue: 12
Pages: e8419-e8419
Citations: 263
Access: Closed

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APA Style

                            
                                    Zhe Ji, 
                                
                                    Bin Tian
                                
                            (2009). 
                            Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types. 
                            PLoS ONE
                            , 4
                            (12)
                            , e8419-e8419.
                            https://doi.org/10.1371/journal.pone.0008419

Identifiers

DOI: 10.1371/journal.pone.0008419