Requirement of bic/microRNA-155 for Normal Immune Function

Abstract

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155 –deficient CD4 + T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Keywords

microRNABiologyImmune systemGeneTranscriptomemiR-155Function (biology)ChemokineCell biologyRegulation of gene expressionComputational biologyGene expressionGenetics

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Publication Info

Year: 2007
Type: article
Volume: 316
Issue: 5824
Pages: 608-611
Citations: 1830
Access: Closed

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APA Style

                            
                                
                                    Antony Rodríguez, 
                                
                                    Elena Vigorito, 
                                
                                    Simon Clare
                                
                                et al.
                            
                            (2007). 
                            Requirement of <i>bic/microRNA-155</i> for Normal Immune Function. 
                            Science
                            , 316
                            (5824)
                            , 608-611.
                            https://doi.org/10.1126/science.1139253
                        

Identifiers

DOI: 10.1126/science.1139253

Requirement of <i>bic/microRNA-155</i> for Normal Immune Function