Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis

Abstract

An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 and triggered a Public Health Emergency of International Concern (PHEIC). We aimed to find risk factors for the progression of COVID-19 to help reducing the risk of critical illness and death for clinical help. The data of COVID-19 patients until March 20, 2020 were retrieved from four databases. We statistically analyzed the risk factors of critical/mortal and non-critical COVID-19 patients with meta-analysis. Male, aged over 65, smoking patients might face a greater risk of developing into the critical or mortal condition and the comorbidities such as hypertension, diabetes, cardiovascular disease, and respiratory diseases could also greatly affect the prognosis of the COVID-19. Clinical manifestation such as fever, shortness of breath or dyspnea and laboratory examination such as WBC, AST, Cr, PCT, LDH, hs-cTnI and D-dimer could imply the progression of COVID-19.

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Affiliated Institutions

• Shaoxing University CN
• Xi'an Jiaotong University CN
• Shaoxing People's Hospital CN
• Sir Run Run Shaw Hospital CN
• People's Hospital of Xinjiang Uygur Autonomous Region CN
• Zhejiang University CN
• Loma Linda University US

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