Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized...

Abstract

Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women. All-cause mortality was not affected during the trial. The risk-benefit profile found in this trial is not consistent with the requirements for a viable intervention for primary prevention of chronic diseases, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.

Keywords

MedicineWomen's Health InitiativeMedroxyprogesterone acetateHazard ratioRandomized controlled trialPlaceboHormone therapyGynecologyEndometrial cancerAdverse effectStroke (engine)Hormone replacement therapy (female-to-male)Internal medicineBreast cancerEstrogenObservational studyConfidence intervalCancer

Affiliated Institutions

Related Publications

The Decrease in Breast-Cancer Incidence in 2003 in the United States

Peter M. Ravdin , Kathleen A. Cronin , Nadia Howlader +5 more

An initial analysis of data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registries shows that the age-adjusted incidence rate of brea...

2007 New England Journal of Medicine 974 citations

National Institutes of Health Consensus Development Conference Statement: Adjuvant Therapy for Breast Cancer, November 1-3, 2000

Patricia J. Eifel , Jan Axelson , Janitha Costa +11 more

The panel concludes that decisions regarding adjuvant hormonal therapy should be based on the presence of hormone receptor protein in tumor tissues. Adjuvant hormonal therapy sh...

2001 JNCI Journal of the National Cancer I... 894 citations

Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone

Christine Brot , Peter Vestergaard , Niels Kolthoff +3 more

We conducted this study to assess the prevalence of vitamin D insufficiency in a population of normal perimenopausal women, to examine the influence of sun exposure and vitamin ...

2001 British Journal Of Nutrition 269 citations

Publication Info

Year: 2002
Type: article
Volume: 288
Issue: 3
Pages: 321-333
Citations: 15602
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

15602

OpenAlex

Cite This

APA Style

                            
                                
                                    Jacques E. Rossouw, 
                                
                                    Garnet L. Anderson, 
                                
                                    Ross L. Prentice
                                
                                et al.
                            
                            (2002). 
                            Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial. 
                            JAMA
                            , 288
                            (3)
                            , 321-333.
                            https://doi.org/10.1001/jama.288.3.321
                        

Identifiers

DOI: 10.1001/jama.288.3.321