Abstract
Summary: Viral infection is detected by cellular sensor molecules as foreign nucleic acids and initiates innate antiviral responses, including the activation of proinflammatory cytokines and type I interferon (IFN). Recent identification of cytoplasmic viral sensors, such as retinoic acid‐inducible gene‐I‐like receptors (RLRs), highlights their significance in the induction of antiviral innate immunity. Moreover, it is intriguing to understand how they can discriminate endogenous RNA from foreign viral RNA and initiate signaling cascades leading to the induction of type I IFNs. This review focuses on the current understanding of the molecular machinery underlying RNA recognition and subsequent signal transduction by RLRs.
Keywords
BiologyPattern recognition receptorInnate immune systemSignal transductionRIG-IRNAProinflammatory cytokineCell biologyInterferonReceptorNucleic acidImmunologyGeneGeneticsInflammation
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Publication Info
- Year
- 2008
- Type
- review
- Volume
- 227
- Issue
- 1
- Pages
- 54-65
- Citations
- 581
- Access
- Closed
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Cite This
Mitsutoshi Yoneyama,
Takashi Fujita
(2008).
RNA recognition and signal transduction by RIG‐I‐like receptors.
Immunological Reviews
, 227
(1)
, 54-65.
https://doi.org/10.1111/j.1600-065x.2008.00727.x
Identifiers
- DOI
- 10.1111/j.1600-065x.2008.00727.x