Abstract

A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D.

Keywords

Gut floraType 2 diabetesPathophysiologyMicrobiomeGut microbiomeBiologyGut–brain axisDiabetes mellitusBioinformaticsMedicineImmunologyEndocrinology

MeSH Terms

HumansBacteriaDiabetes MellitusType 2Gastrointestinal Microbiome

Affiliated Institutions

Related Publications

Publication Info

Year
2020
Type
review
Volume
51
Pages
102590-102590
Citations
1559
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1559
OpenAlex
58
Influential
1390
CrossRef

Cite This

Manoj Gurung, Zhipeng Li, Hannah You et al. (2020). Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine , 51 , 102590-102590. https://doi.org/10.1016/j.ebiom.2019.11.051

Identifiers

DOI
10.1016/j.ebiom.2019.11.051
PMID
31901868
PMCID
PMC6948163

Data Quality

Data completeness: 90%