SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Constantinos Kurt Wibmer; Frances Ayres; Tandile Hermanus; Mashudu Madzivhandila; Prudence Kgagudi; Brent Oosthuysen; Bronwen E. Lambson; Túlio de Oliveira; Marion Vermeulen; Karin van den Berg; Theresa M. Rossouw; Michael T. Boswell; Veronica Ueckermann; Susan Meiring; Anne von Gottberg; Cheryl Cohen; Lynn Morris; Jinal N. Bhiman; Penny L. Moore

doi:10.1038/s41591-021-01285-x

Keywords

NeutralizationConvalescent plasmaSpike ProteinVirologyMonoclonal antibodyAntibodyLineage (genetic)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Recombinant DNACoronavirusBiologySpike (software development)2019-20 coronavirus outbreakGeneGeneticsMedicine

Affiliated Institutions

Related Publications

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Yiska Weisblum , Fabian Schmidt , Fengwen Zhang +21 more

Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2. Moreover, passiv...

2020 eLife 1439 citations

Detection of a SARS-CoV-2 variant of concern in South Africa

Houriiyah Tegally , Eduan Wilkinson , Marta Giovanetti +44 more

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newl...

2021 Nature 1775 citations

Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa

Houriiyah Tegally , Eduan Wilkinson , Marta Giovanetti +44 more

Summary Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for...

2020 bioRxiv (Cold Spring Harbor Laboratory) 1193 citations

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Philip J. M. Brouwer , Tom G. Caniels , Karlijn van der Straten +30 more

Sites of vulnerability in SARS-CoV-2 Antibodies that neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be an important tool in treating coronavirus d...

2020 Science 1318 citations

Site-specific glycan analysis of the SARS-CoV-2 spike

Yasunori Watanabe , Joel D. Allen , Daniel Wrapp +2 more

SARS-CoV-2 spike protein, elaborated Vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on the trimeric spike protein that initiates...

2020 Science 1648 citations

Publication Info

Year: 2021
Type: article
Volume: 27
Issue: 4
Pages: 622-625
Citations: 1256
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1256

OpenAlex

Cite This

APA Style

                            
                                
                                    Constantinos Kurt Wibmer, 
                                
                                    Frances Ayres, 
                                
                                    Tandile Hermanus
                                
                                et al.
                            
                            (2021). 
                            SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. 
                            Nature Medicine
                            , 27
                            (4)
                            , 622-625.
                            https://doi.org/10.1038/s41591-021-01285-x
                        

Identifiers

DOI: 10.1038/s41591-021-01285-x