Abstract
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.
Keywords
Cytokine stormCoronavirus disease 2019 (COVID-19)CoronavirusImmunologyPandemicImmune systemMedicineCytokineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakCytokine release syndromeCD8BetacoronavirusVirologyDiseaseInfectious disease (medical specialty)Internal medicineOutbreak
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Publication Info
- Year
- 2020
- Type
- article
- Volume
- 130
- Issue
- 5
- Pages
- 2202-2205
- Citations
- 1206
- Access
- Closed
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Cite This
Savannah F. Pedersen,
Ya‐Chi Ho
(2020).
SARS-CoV-2: a storm is raging.
Journal of Clinical Investigation
, 130
(5)
, 2202-2205.
https://doi.org/10.1172/jci137647
Identifiers
- DOI
- 10.1172/jci137647