SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Keywords

TMPRSS2ProteasesBiologyViral entryVirologyCoronavirusProteaseReceptorSerine proteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Priming (agriculture)Protease inhibitor (pharmacology)BetacoronavirusCoronavirus disease 2019 (COVID-19)VirusImmunologyViral replicationGeneticsViral loadEnzymeMedicineDisease

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Publication Info

Year: 2020
Type: article
Volume: 181
Issue: 2
Pages: 271-280.e8
Citations: 20901
Access: Closed

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APA Style

                            
                                
                                    Markus Hoffmann, 
                                
                                    Hannah Kleine‐Weber, 
                                
                                    Simon Schroeder
                                
                                et al.
                            
                            (2020). 
                            SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. 
                            Cell
                            , 181
                            (2)
                            , 271-280.e8.
                            https://doi.org/10.1016/j.cell.2020.02.052
                        

Identifiers

DOI: 10.1016/j.cell.2020.02.052