Search for risk factors for slowed intra-atrial conduction in patients with schizophrenia

Abstract

Objective. To study the risk factors for a slowed intra-atrial conduction in patients with schizophrenia. Material and methods. One hundred twenty-two electrocardiograms of patients with schizophrenia who took antipsychotics were analyzed. The components of the metabolic syndrome, as well as anthropometric parameters, were identified as potential risk factors. Results. Slowed intra-atrial conduction (P >0.10 s) was found in 21 (17.2%) patients. Therefore, the patients were divided into two groups depending on the presence or absence of slowed intra-atrial conduction. Male sex (p=0.031), the duration of basic therapy (p<0.001), hypertriglyceridemia (p=0.043), the presence of metabolic syndrome (p=0.015), and hypersthenic body type (p<0.001) were statistically significant risk factors for slowed intra-atrial conduction in patients with schizophrenia. Conclusion. If these risk factors are identified in patients with schizophrenia, continuous monitoring of the electrocardiogram and pharmacological interventions are recommended for the identified indications.

Affiliated Institutions

• Mental Health Research Institute AU
• Russian Academy of Sciences RU
• Tomsk National Research Medical Center RU

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