Abstract
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.
Keywords
NanofiberAmphiphileMineralization (soil science)PeptideBiomineralizationExtracellular matrixSelf-assemblyFibrilMaterials scienceBiophysicsChemistryChemical engineeringNanotechnologyPolymerComposite materialBiochemistryCopolymerOrganic chemistry
Affiliated Institutions
Related Publications
Apatite formation on three kinds of bioactive material at an early stage <i>in vivo</i>: A comparative study by transmission electron microscopy
Abstract Apatite formation on the surface of three kinds of bioactive material at an early stage after implantation in bone was studied using transmission electron microscopy (T...
Composition Options for Tissue-Engineered Bone
The logical assembly of tissue-engineered bone is ultimately directed by the clinical status of the patient. The basic elements for tissue-engineered bone should include signali...
Collagen Structure and Stability
Collagen is the most abundant protein in animals. This fibrous, structural protein comprises a right-handed bundle of three parallel, left-handed polyproline II-type helices. Mu...
Review of Recent Research into Cellulosic Whiskers, Their Properties and Their Application in Nanocomposite Field
There are numerous examples where animals or plants synthesize extracellular high-performance skeletal biocomposites consisting of a matrix reinforced by fibrous biopolymers. Ce...
Adhesion and Surface Issues in Cellulose and Nanocellulose
Abstract This paper provides a review of the scientific literature concerned with adhesion and surface properties of cellulose and nanocellulose. Cellulose is the most abundant ...
Publication Info
- Year
- 2001
- Type
- article
- Volume
- 294
- Issue
- 5547
- Pages
- 1684-1688
- Citations
- 3546
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
3546
OpenAlex
Cite This
Jeffrey D. Hartgerink,
Elia Beniash,
Samuel I. Stupp
(2001).
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers.
Science
, 294
(5547)
, 1684-1688.
https://doi.org/10.1126/science.1063187
Identifiers
- DOI
- 10.1126/science.1063187