Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.

Zhengming Chen; Richard Peto; Rory Collins; Stephen MacMahon; Jinmei Lu; W Li

doi:10.1136/bmj.303.6797.276

Abstract

Blood cholesterol concentration was directly related to mortality from coronary heart disease even in those with what was, by Western standards, a "low" cholesterol concentration. There was no good evidence of an adverse effect of cholesterol on other causes of death.

Keywords

CholesterolMedicineInternal medicineCardiologyCoronary heart diseasePopulationConfidence intervalCause of deathEndocrinologyDisease

Affiliated Institutions

Related Publications

Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease

Salim Yusuf , Eva Lonn , Prem Pais +29 more

BACKGROUND: Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of c...

2016 New England Journal of Medicine 367 citations

Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart protection study and other major trials

Jane Armitage

Diabetes mellitus contributes substantially to the global burden of disease, with an estimated 100 million people affected worldwide, and its prevalence is increasing rapidly.1 ...

2000 Heart 42 citations

Assessing possible hazards of reducing serum cholesterol

M R Law , Simon G. Thompson , Nicholas Wald

There is no evidence that low or reduced serum cholesterol concentration increases mortality from any cause other than haemorrhagic stroke. This risk affects only those people w...

1994 BMJ 313 citations

Ten-Year Mortality from Cardiovascular Disease in Relation to Cholesterol Level among Men with and without Preexisting Cardiovascular Disease

Juha Pekkanen , Shai Linn , Gerardo Heiss +4 more

To determine the associations of total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol with mortality from coronary heart disease and cardiovascul...

1990 New England Journal of Medicine 831 citations

Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study.

J. H. Fuller , M Shipley , G Rose +2 more

In the Whitehall study of 18 403 male civil servants aged 40-64 years the 10 year mortality rates from coronary heart disease and stroke showed a non-linear relation to two hour...

1983 BMJ 640 citations

Publication Info

Year: 1991
Type: article
Volume: 303
Issue: 6797
Pages: 276-282
Citations: 542
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

542

OpenAlex

Cite This

APA Style

                            
                                
                                    Zhengming Chen, 
                                
                                    Richard Peto, 
                                
                                    Rory Collins
                                
                                et al.
                            
                            (1991). 
                            Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.. 
                            BMJ
                            , 303
                            (6797)
                            , 276-282.
                            https://doi.org/10.1136/bmj.303.6797.276
                        

Identifiers

DOI: 10.1136/bmj.303.6797.276