Sex differences in immune responses that underlie COVID-19 disease outcomes

Takehiro Takahashi , Mallory K. Ellingson , Patrick Wong , Takehiro Takahashi , Mallory K. Ellingson , Patrick Wong , Benjamin Israelow , Carolina Lucas , Jon Klein , Julio Silva , Tianyang Mao , Ji Eun Oh , Maria Tokuyama , Peiwen Lu , Arvind Venkataraman , Annsea Park , Feimei Liu , Amit Meir , Jonathan Sun , Eric Y. Wang , Arnau Casanovas‐Massana , Anne L. Wyllie , Chantal B. F. Vogels , Rebecca Earnest , Sarah Lapidus , Isabel M. Ott , Adam J. Moore , Kelly Anastasio , Michael H. Askenase , Maria Batsu , Hannah E. Beatty , Santos Bermejo , Sean Bickerton , Kristina Brower , Molly L. Bucklin , Staci Cahill , Melissa Campbell , Yiyun Cao , Edward Courchaine , Rupak Datta , Giuseppe DeIuliis , Bertie Geng , Laura Glick , Ryan Handoko , Chaney C. Kalinich , William Khoury-Hanold , Daniel Kim , Lynda Knaggs , Maxine Kuang , Eriko Kudo , Joseph K. Lim , Melissa Linehan , Alice Lu-Culligan , Amyn A. Malik , Anjelica Martin , Irene Matos , David McDonald , Maksym Minasyan , Subhasis Mohanty , M. Catherine Muenker , Nida Naushad , Allison Nelson , Jessica Nouws , Marcella Nuñez-Smith , Abeer Obaid , Isabel M. Ott , Hong‐Jai Park , Xiaohua Peng , Mary E. Petrone , Sarah Prophet , Harold Rahming , Tyler Rice , Kadi-Ann Rose , Lorenzo R. Sewanan , Lokesh Sharma , Denise Shepard , Erin Silva , Michael Simonov , Mikhail Smolgovsky , Eric Song , Nicole Sonnert , Yvette Strong , Codruta Todeasa , Jordan Valdez , Sofia Velazquez , Pavithra Vijayakumar , Haowei Wang , Annie Watkins , Elizabeth B. White , Yexin Yang , Albert C. Shaw , John Fournier , Camila D. Odio , Shelli Farhadian , Charles S. Dela Cruz , Nathan D. Grubaugh , Wade L. Schulz , Aaron M. Ring , Albert I. Ko , Saad B. Omer , Akiko Iwasaki
2020 Nature 1,442 citations

Keywords

Coronavirus disease 2019 (COVID-19)Disease2019-20 coronavirus outbreakImmune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus InfectionsMedicinePandemicBetacoronavirusBiologyImmunologyVirologyInfectious disease (medical specialty)OutbreakInternal medicine

MeSH Terms

COVID-19ChemokinesCohort StudiesCytokinesDisease ProgressionFemaleHumansImmunityInnateLymphocyte ActivationMaleMonocytesPhenotypePrognosisRNAViralSARS-CoV-2Sex CharacteristicsT-LymphocytesViral Load

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Publication Info

Year
2020
Type
article
Volume
588
Issue
7837
Pages
315-320
Citations
1442
Access
Closed

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Cite This

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong et al. (2020). Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature , 588 (7837) , 315-320. https://doi.org/10.1038/s41586-020-2700-3

Identifiers

DOI
10.1038/s41586-020-2700-3
PMID
32846427
PMCID
PMC7725931

Data Quality

Data completeness: 72%