Abstract

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, SIFT has become one of the standard tools for characterizing missense variation. We have updated SIFT's genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deletion (indel) tool. We also show accuracy metrics on independent data sets. The original developers have hosted the SIFT web server at FHCRC, JCVI and the web server is currently located at BII. The URL is http://sift-dna.org (24 May 2012, date last accessed).

Keywords

Scale-invariant feature transformIndelBiologyWeb serverComputational biologyThe InternetComputer scienceMissense mutationGeneticsBioinformaticsMutationGeneArtificial intelligenceWorld Wide WebFeature extractionSingle-nucleotide polymorphism

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Publication Info

Year
2012
Type
article
Volume
40
Issue
W1
Pages
W452-W457
Citations
2357
Access
Closed

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Ngak-Leng Sim, P. Naresh Kumar, Jing Hu et al. (2012). SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Research , 40 (W1) , W452-W457. https://doi.org/10.1093/nar/gks539

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DOI
10.1093/nar/gks539