Keywords
Affiliated Institutions
Related Publications
Intracellular Signaling by the Unfolded Protein Response
The unfolded protein response (UPR) is an intracellular signaling pathway that is activated by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activ...
Mechanisms, regulation and functions of the unfolded protein response
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases, incl...
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for ...
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
Unfolded proteins in the endoplasmic reticulum (ER) activate the ER transmembrane sensor Ire1 to trigger the unfolded protein response (UPR), a homeostatic signaling pathway tha...
Eating the endoplasmic reticulum: quality control by autophagy
Autophagy is connected to a surprising range of cellular processes, including the stress response, developmental remodeling, organelle homeostasis and disease pathophysiology. T...
Publication Info
- Year
- 2007
- Type
- review
- Volume
- 8
- Issue
- 7
- Pages
- 519-529
- Citations
- 6165
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1038/nrm2199