Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

Abstract

The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v- sis , and a human platelet-derived growth factor. The mechanism by which v- sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.

Keywords

GeneBiologyVirusGrowth factorSarcomaSimianGene expressionTransforming growth factorVirologyMolecular biologyGeneticsCell biologyReceptorMedicinePathology

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Publication Info

Year: 1983
Type: article
Volume: 221
Issue: 4607
Pages: 275-277
Citations: 1546
Access: Closed

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APA Style

                            
                                
                                    Russell F. Doolittle, 
                                
                                    Michael W. Hunkapiller, 
                                
                                    Leroy Hood
                                
                                et al.
                            
                            (1983). 
                            Simian Sarcoma Virus <i>onc</i> Gene, v- <i>sis</i> , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor. 
                            Science
                            , 221
                            (4607)
                            , 275-277.
                            https://doi.org/10.1126/science.6304883
                        

Identifiers

DOI: 10.1126/science.6304883