Single-cell connectomic analysis of adult mammalian lungs

Micha Sam Brickman Raredon; Taylor Adams; Yasir Suhail; Jonas C. Schupp; Sergio Poli; Nir Neumark; Katherine L. Leiby; Allison M. Greaney; Yifan Yuan; Corey Horien; George C. Linderman; Alexander J. Engler; Daniel J. Boffa; Yuval Kluger; Iván O. Rosas; Andre Levchenko; Naftali Kaminski; Laura E. Niklason

doi:10.1126/sciadv.aaw3851

Abstract

Single-cell network analysis demonstrates species-conserved functional roles for pulmonary alveolar cell types.

Keywords

CellCell typeFunctional analysisSingle-cell analysisCell biologyComputational biologyBiologyMedicinePathologyGeneticsGene

Affiliated Institutions

Related Publications

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Paul A. Reyfman , James M. Walter , Nikita Joshi +46 more

<b>Rationale:</b> The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal...

2018 American Journal of Respiratory and C... 1198 citations

Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer , Lori E. Kotch , Faton Agani +8 more

Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortalit...

1998 Genes & Development 2458 citations

Cells of the adult human heart

Monika Litviňuková , Carlos Talavera‐López , Henrike Maatz +30 more

Abstract Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of t...

2020 Nature 1577 citations

Conserved cell types with divergent features in human versus mouse cortex

Rebecca D. Hodge , Trygve E. Bakken , Jeremy A. Miller +61 more

Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus...

2019 Nature 1796 citations

Mapping the Mouse Cell Atlas by Microwell-Seq

Xiaoping Han , Renying Wang , Yincong Zhou +25 more

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current cell-type classification system. However, a transcriptome-based single-cell atlas has not b...

2018 Cell 1628 citations

Publication Info

Year: 2019
Type: article
Volume: 5
Issue: 12
Pages: eaaw3851-eaaw3851
Citations: 228
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Single-cell connectomic analysis of adult mammalian lungs

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

228

OpenAlex

Cite This

APA Style

                            
                                
                                    Micha Sam Brickman Raredon, 
                                
                                    Taylor Adams, 
                                
                                    Yasir Suhail
                                
                                et al.
                            
                            (2019). 
                            Single-cell connectomic analysis of adult mammalian lungs. 
                            Science Advances
                            , 5
                            (12)
                            , eaaw3851-eaaw3851.
                            https://doi.org/10.1126/sciadv.aaw3851
                        

Identifiers

DOI: 10.1126/sciadv.aaw3851