Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Keywords

LGR5Stem cellCryptOrganoidBiologyCell biologyEpitheliumMesenchymal stem cellAdult stem cellStem cell nicheIntestinal epitheliumRegenerative medicineNicheCellular differentiationIntestinal mucosaIn vitroCancer stem cellEndothelial stem cellGeneticsProgenitor cellInternal medicineMedicineEndocrinologyBiochemistry

Affiliated Institutions

Related Publications

The intestinal stem cell

Nick Barker , Marc van de Wetering , Hans Clevers

The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal different...

2008 Genes & Development 602 citations

Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies

Patricia A. Zuk , Min Zhu , Hiroshi Mizuno +6 more

Future cell-based therapies such as tissue engineering will benefit from a source of autologous pluripotent stem cells. For mesodermal tissue engineering, one such source of cel...

2001 Tissue Engineering 7881 citations

Mesenchymal stem cell perspective: cell biology to clinical progress

Mark F. Pittenger , Dennis E. Discher , Bruno Péault +3 more

The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell population of multipotential stem/progenitor cells commonly referred to as mesenchymal ste...

2019 npj Regenerative Medicine 1874 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine I. Columnar cell

Hazel Cheng , C. P. Leblond

Abstract The columnar cells, i.e., the cells which contain neither mucous globules, nor entero‐endocrine granules, nor Paneth type secretion, were investigated independently of ...

1974 American Journal of Anatomy 584 citations

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Anna-Pavlina G. Haramis , Harry Begthel , Maaike van den Born +4 more

Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into crypts and villi. With the use of mouse models, we ...

2004 Science 760 citations

Publication Info

Year: 2009
Type: article
Volume: 459
Issue: 7244
Pages: 262-265
Citations: 6749
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

6749

OpenAlex

Cite This

APA Style

                            
                                
                                    Toshiro Sato, 
                                
                                    Robert G.J. Vries, 
                                
                                    Hugo J.G. Snippert
                                
                                et al.
                            
                            (2009). 
                            Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. 
                            Nature
                            , 459
                            (7244)
                            , 262-265.
                            https://doi.org/10.1038/nature07935
                        

Identifiers

DOI: 10.1038/nature07935