Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice

Xiaocheng Zhu; Lizhe Guo; Na Chen; Lu Wang; Sisi Dai; X Y Liu; Xiang Chen; Caiyi Wang; Yanan Cao; Hao Hu; E Wang

doi:10.1080/07853890.2025.2599059

Abstract

SF may aggravate MI/RI through PVN OX1R-associated sympathetic hyperactivation. Pharmacological inhibition of OX1R improved cardiac outcomes, supporting the involvement of the PVN OX1R-sympathetic pathway in sleep disruption related cardiac injury.

Affiliated Institutions

Related Publications

Developing a Predictive Model for Ischemic Stroke Onset Time Using Transfer Learning

Yang Du , Shuai Wang , Weidong Wang +6 more

Introduction Identification of acute ischemic stroke (AIS) patients within the 4.5-hour therapeutic window is critical for therapy. Diffusion-weighted imaging (DWI) and fluid-at...

2025 European Neurology 0 citations

Clinical determinants for fatality of 44,672 patients with COVID-19

Guangtong Deng , Mingzhu Yin , Xiang Chen +1 more

2020 Critical Care 274 citations

Radiation Resistant Camera System for Monitoring Deuterium Plasma Discharges in the Large Helical Device

M. Shoji

Radiation resistant camera system was constructed for monitoring deuterium plasma discharges in the Large Helical Device (LHD). This system has contributed to safe operation dur...

2020 Plasma and Fusion Research 801215 citations

R: A Language and Environment for Statistical Computing

R Core Team

2000 352806 citations

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

OliverH. Lowry , NiraJ. Rosebrough , A. Farr +1 more

Since 1922 when Wu proposed the use of the Folin phenol reagent for the measurement of proteins (l), a number of modified analytical procedures ut.ilizing this reagent have been...

1951 Journal of Biological Chemistry 316796 citations

Publication Info

Year: 2025
Type: article
Volume: 57
Issue: 1
Pages: 2599059-2599059
Citations: 0
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Xiaocheng Zhu, 
                                
                                    Lizhe Guo, 
                                
                                    Na Chen
                                
                                et al.
                            
                            (2025). 
                            Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice. 
                            Annals of Medicine
                            , 57
                            (1)
                            , 2599059-2599059.
                            https://doi.org/10.1080/07853890.2025.2599059
                        

Identifiers

DOI: 10.1080/07853890.2025.2599059