SMART: a web-based tool for the study of genetically mobile domains

Abstract

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.

Keywords

BiologyPhyletic gradualismModular designComputational biologyDomain (mathematical analysis)AnnotationIdentification (biology)Protein domainDatabaseBioinformaticsComputer scienceGeneticsPhylogeneticsGeneProgramming language

Affiliated Institutions

European Molecular Biology Organization DE

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Publication Info

Year: 2000
Type: article
Volume: 28
Issue: 1
Pages: 231-234
Citations: 1397
Access: Closed

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APA Style

                            
                                    J. Schultz
                                
                            (2000). 
                            SMART: a web-based tool for the study of genetically mobile domains. 
                            Nucleic Acids Research
                            , 28
                            (1)
                            , 231-234.
                            https://doi.org/10.1093/nar/28.1.231

Identifiers

DOI: 10.1093/nar/28.1.231