Abstract
A method is presented for analytically calculating a smooth, three-dimensional contour about a molecule. The molecular surface envelope may be drawn on either color raster computer displays or real-time vector computer graphics systems. Molecular areas and volumes may be computed analytically from this surface representation. Unlike most previous computer graphics representations of molecules, which imitate wire models or space-filling plastic spheres, this surface shows only the atoms that are accessible to solvent. This analytical method extends the earlier dot surface numerical algorithm, which has been applied in enzymology, rational drug design, immunology, and understanding DNA base sequence recognition.
Keywords
Molecular graphicsRaster graphicsSurface (topology)Computer graphicsRepresentation (politics)MoleculeNucleic acidGraphicsSequence (biology)Computer graphics (images)Biological systemComputer scienceChemistryGeometryMathematicsBiology
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Publication Info
- Year
- 1983
- Type
- article
- Volume
- 221
- Issue
- 4612
- Pages
- 709-713
- Citations
- 2715
- Access
- Closed
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Cite This
Michael L. Connolly
(1983).
Solvent-Accessible Surfaces of Proteins and Nucleic Acids.
Science
, 221
(4612)
, 709-713.
https://doi.org/10.1126/science.6879170
Identifiers
- DOI
- 10.1126/science.6879170