Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant; Niklas Schultz; Huw D. Thomas; Kayan M. Parker; Dan Flower; Elena López‐Knowles; Suzanne Kyle; Mark Meuth; Nicola J. Curtin; Thomas Helleday

doi:10.1038/nature03443

Keywords

Homologous recombinationRAD51Poly ADP ribose polymerasePARP1DNA repairPolymerasePARP inhibitorBiologyBRCA2 ProteinOlaparibDNA damageVeliparibSynthetic lethalityMolecular biologyBase excision repairDNACancer researchMutationGeneticsGermline mutationGene

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Publication Info

Year: 2005
Type: article
Volume: 434
Issue: 7035
Pages: 913-917
Citations: 4992
Access: Closed

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APA Style

                            
                                
                                    Helen E. Bryant, 
                                
                                    Niklas Schultz, 
                                
                                    Huw D. Thomas
                                
                                et al.
                            
                            (2005). 
                            Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. 
                            Nature
                            , 434
                            (7035)
                            , 913-917.
                            https://doi.org/10.1038/nature03443
                        

Identifiers

DOI: 10.1038/nature03443