Abstract
The main purpose of this article is to present several new statistical tests of neutrality of mutations against a class of alternative models, under which DNA polymorphisms tend to exhibit excesses of rare alleles or young mutations. Another purpose is to study the powers of existing and newly developed tests and to examine the detailed pattern of polymorphisms under population growth, genetic hitchhiking and background selection. It is found that the polymorphic patterns in a DNA sample under logistic population growth and genetic hitchhiking are very similar and that one of the newly developed tests, FS, is considerably more powerful than existing tests for rejecting the hypothesis of neutrality of mutations. Background selection gives rise to quite different polymorphic patterns than does logistic population growth or genetic hitchhiking, although all of them show excesses of rare alleles or young mutations. We show that Fu and Li's tests are among the most powerful tests against background selection. Implications of these results are discussed.
Keywords
BiologySelection (genetic algorithm)GeneticsNeutralityNeutral mutationPopulationAlleleEvolutionary biologyMutationBackground selectionAllele frequencyNeutral theory of molecular evolutionPopulation geneticsGeneDemography
MeSH Terms
ModelsGeneticModelsStatisticalMutationPolymorphismGeneticPopulation GrowthSelectionGenetic
Affiliated Institutions
Related Publications
Deleterious- and Disease-Allele Prevalence in Healthy Individuals: Insights from Current Predictions, Mutation Databases, and Population-Scale Resequencing
We have assessed the numbers of potentially deleterious variants in the genomes of apparently healthy humans by using (1) low-coverage whole-genome sequence data from 179 indivi...
<scp>micro</scp>‐<scp>checker</scp>: software for identifying and correcting genotyping errors in microsatellite data
Abstract DNA degradation, low DNA concentrations and primer‐site mutations may result in the incorrect assignment of microsatellite genotypes, potentially biasing population gen...
Apparent heterozygote deficiencies observed in DNA typing data and their implications in forensic applications
Summary Restriction fragment length polymorphisms (RFLP) analysis using the Southern blot technique can be used to recognize copy number variation of variable number of tandem r...
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION
T has sometimes been suggested that the wild-type allele is not a single entity, I but rather a population of different isoalleles that are indistinguishable by any ordinary pro...
Joint Inference of Microsatellite Mutation Models, Population History and Genealogies Using Transdimensional Markov Chain Monte Carlo
Abstract We provide a framework for Bayesian coalescent inference from microsatellite data that enables inference of population history parameters averaged over microsatellite m...
Publication Info
- Year
- 1997
- Type
- article
- Volume
- 147
- Issue
- 2
- Pages
- 915-925
- Citations
- 7067
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
7067
OpenAlex
5655
CrossRef
Cite This
Yun‐Xin Fu
(1997).
Statistical Tests of Neutrality of Mutations Against Population Growth, Hitchhiking and Background Selection.
Genetics
, 147
(2)
, 915-925.
https://doi.org/10.1093/genetics/147.2.915
Identifiers
- DOI
- 10.1093/genetics/147.2.915
- PMID
- 9335623
- PMCID
- PMC1208208