Abstract
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Keywords
CoronavirusProtein subunitVirologyBiologyReceptorSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Drug discoveryCoronavirus disease 2019 (COVID-19)Viral entryLipid bilayer fusionAngiotensin-converting enzyme 2Drug developmentProtein structureComputational biologyDrugBioinformaticsVirusMedicineInfectious disease (medical specialty)PharmacologyBiochemistryViral replicationDiseaseGene
MeSH Terms
Antiviral AgentsBetacoronavirusCOVID-19Coronavirus InfectionsDrug DiscoveryHumansPandemicsPneumoniaViralSARS-CoV-2Spike GlycoproteinCoronavirusVirus Internalization
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Publication Info
- Year
- 2020
- Type
- review
- Volume
- 41
- Issue
- 9
- Pages
- 1141-1149
- Citations
- 2321
- Access
- Closed
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Cite This
Yuan Huang,
Chan Yang,
Xin-feng Xu
et al.
(2020).
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.
Acta Pharmacologica Sinica
, 41
(9)
, 1141-1149.
https://doi.org/10.1038/s41401-020-0485-4
Identifiers
- DOI
- 10.1038/s41401-020-0485-4
- PMID
- 32747721
- PMCID
- PMC7396720