Abstract
The pathogenesis of intraventricular hemorrhage in the newborn includes that of subependymal hemorrhage (SEH), the single most common pathologic alteration seen in the brains of 417 consecutively autopsied infants. A clearly recognizable relationship of SEH to gestational age and clinical status exists in that all SEH occur in premature infants under 2500 g birthweight (although only 56% of all premature infants have SEH) and 95% of SEH occur in infants with the respiratory distress syndrome (although only 60% of infants with the respiratory distress syndrome have SEH). The pathogenesis appears to involve a combination of hypoxia, metabolic acidosis, venous stasis and rupture of the thin-walled veins so prominent in the germinal matrix.
Keywords
Germinal matrixRespiratory distressIntraventricular hemorrhageMedicineSubependymal zonePathogenesisHypoxia (environmental)PathologyGestational agePediatricsInternal medicineAnesthesiaPregnancyBiology
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Publication Info
- Year
- 1974
- Type
- article
- Volume
- 77
- Issue
- 3
- Pages
- 465-75
- Citations
- 175
- Access
- Closed
External Links
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Cite This
Richard W. Leech,
P W Kohnen
(1974).
Subependymal and intraventricular hemorrhages in the newborn..
PubMed
, 77
(3)
, 465-75.