Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

Nancy Boudreau; Carolyn J. Sympson; Zena Werb; Mina J. Bissell

doi:10.1126/science.7531366

Abstract

Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to β 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1β converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.

Keywords

Extracellular matrixFibronectinCell biologyApoptosisBasement membraneIntegrinProgrammed cell deathBiologyChemistryCellBiochemistry

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Publication Info

Year: 1995
Type: article
Volume: 267
Issue: 5199
Pages: 891-893
Citations: 1178
Access: Closed

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APA Style

                            
                                
                                    Nancy Boudreau, 
                                
                                    Carolyn J. Sympson, 
                                
                                    Zena Werb
                                
                                et al.
                            
                            (1995). 
                            Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix. 
                            Science
                            , 267
                            (5199)
                            , 891-893.
                            https://doi.org/10.1126/science.7531366
                        

Identifiers

DOI: 10.1126/science.7531366