Abstract

Formation, differentiation and plasticity of synapses, the specialized cell-cell contacts through which neurons communicate, all require interactions between pre- and post-synaptic partners. Several synaptically localized adhesion molecules potentially capable of mediating these interactions have been identified recently. Functional studies suggest roles for some of them in target recognition (e.g. SYG-1 and sidekicks), formation and alignment of synaptic specializations (e.g. SynCAM, neuroligin and neurexin), and regulation of synaptic structure and function (e.g. cadherins and syndecan).

Keywords

BiologyNeuroliginNeurexinCell adhesion moleculeNeuroscienceSynaptic plasticitySynaptogenesisSynapseCell adhesionCell biologyCellPostsynaptic potentialExcitatory postsynaptic potentialReceptorGenetics

MeSH Terms

Amino Acid SequenceAnimalsAxonsCadherinsCaenorhabditis elegans ProteinsCell Adhesion MoleculesCytoskeletonGTP-Binding ProteinsImmunoglobulinsNerve Tissue ProteinsNeural Cell Adhesion MoleculesProtein StructureTertiarySynapsesSynaptic TransmissionSynaptic Vesicles

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Publication Info

Year
2003
Type
review
Volume
15
Issue
5
Pages
621-632
Citations
364
Access
Closed

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Cite This

Masahito Yamagata, Joshua R. Sanes, Joshua A. Weiner (2003). Synaptic adhesion molecules. Current Opinion in Cell Biology , 15 (5) , 621-632. https://doi.org/10.1016/s0955-0674(03)00107-8

Identifiers

DOI
10.1016/s0955-0674(03)00107-8
PMID
14519398

Data Quality

Data completeness: 86%