Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

Abstract

The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals. Therefore, both factors are important to consider in upcoming secondary prevention trials targeting CN individuals at high risk for progression to the symptomatic stages of Alzheimer disease.

Keywords

Cognitive declineNeuroimagingAlzheimer's Disease Neuroimaging InitiativeNeurodegenerationPittsburgh compound BPositron emission tomographyNeuropsychologyAlzheimer's diseaseMedicineCognitionInternal medicineOdds ratioPsychologyMagnetic resonance imagingDiseasePsychiatryDementiaNeuroscienceRadiology

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Publication Info

Year: 2014
Type: article
Volume: 71
Issue: 11
Pages: 1379-1379
Citations: 308
Access: Closed

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APA Style

                            
                                
                                    Elizabeth C. Mormino, 
                                
                                    Rebecca A. Betensky, 
                                
                                    Trey Hedden
                                
                                et al.
                            
                            (2014). 
                            Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals. 
                            JAMA Neurology
                            , 71
                            (11)
                            , 1379-1379.
                            https://doi.org/10.1001/jamaneurol.2014.2031
                        

Identifiers

DOI: 10.1001/jamaneurol.2014.2031