Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs

Toshimitsu Konno; Ken Iwai; Minoru Ueda; Hiroshi Maeda; Tomonori Matsumoto

doi:10.1007/bf01040499

Keywords

NeocarzinostatinConjugateChemistryAntigenicityMolecular massCamptothecinConjugated systemCombinatorial chemistryBiochemistryPolymerDNABiologyAntibodyEnzymeOrganic chemistry

Affiliated Institutions

Related Publications

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda , Yasuhiro Matsumura

The advantages and disadvantages of macromolecular drugs, particularly on synthetic polymer-protein conjugates, are described in this article. Improvements in protein drugs, aft...

1989 PubMed 580 citations

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura , Hiroshi Maeda

We previously found that a polymer conjugated to the anticancer protein neocarzinostatin, named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine...

1986 PubMed 6797 citations

Monoclonal Antibody Therapy for Cancer

Margaret von Mehren , Gregory P. Adams , Louis M. Weiner

Monoclonal antibody therapy has emerged as an important therapeutic modality for cancer. Unconjugated antibodies show significant efficacy in the treatment of breast cancer, non...

2003 Annual Review of Medicine 188 citations

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

Gregory P. Adams , Robert Schier , Adrian M. McCall +5 more

Antitumor monoclonal antibodies must bind to tumor antigens with high affinity to achieve durable tumor retention. This has spurred efforts to generate high affinity antibodies ...

2001 PubMed 625 citations

Publication Info

Year: 1984
Type: review
Volume: 3
Issue: 2
Pages: 181-193
Citations: 114
Access: Closed

External Links

Download PDF (Free) View on DOI.org Semantic Scholar

Social Impact

Altmetric

Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

114

OpenAlex

Influential

Cite This

APA Style

                            
                                
                                    Toshimitsu Konno, 
                                
                                    Ken Iwai, 
                                
                                    Minoru Ueda
                                
                                et al.
                            
                            (1984). 
                            Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs. 
                            Journal of Protein Chemistry
                            , 3
                            (2)
                            , 181-193.
                            https://doi.org/10.1007/bf01040499
                        

Identifiers

DOI: 10.1007/bf01040499

Data Quality

Data completeness: 63%