TANDEM: matching proteins with tandem mass spectra

Abstract

Abstract Summary: Tandem mass spectra obtained from fragmenting peptide ions contain some peptide sequence specific information, but often there is not enough information to sequence the original peptide completely. Several proprietary software applications have been developed to attempt to match the spectra with a list of protein sequences that may contain the sequence of the peptide. The application TANDEM was written to provide the proteomics research community with a set of components that can be used to test new methods and algorithms for performing this type of sequence-to-data matching. Availability: The source code and binaries for this software are available at http://www.proteome.ca/opensource.html, for Windows, Linux and Macintosh OSX. The source code is made available under the Artistic License, from the authors.

Keywords

TandemMatching (statistics)Tandem repeatTandem mass spectrometryComputer scienceComputational biologyChemistryBiologyGeneticsMass spectrometryChromatographyMathematicsGenomeStatisticsMaterials science

Affiliated Institutions

University of Manitoba CA

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Publication Info

Year: 2004
Type: article
Volume: 20
Issue: 9
Pages: 1466-1467
Citations: 2566
Access: Closed

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APA Style

                            
                                    Robertson Craig, 
                                
                                    Ronald C. Beavis
                                
                            (2004). 
                            TANDEM: matching proteins with tandem mass spectra. 
                            Bioinformatics
                            , 20
                            (9)
                            , 1466-1467.
                            https://doi.org/10.1093/bioinformatics/bth092

Identifiers

DOI: 10.1093/bioinformatics/bth092