The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

Keywords

BiologyGenome-wide association studyMendelian randomizationGenetic architectureGeneticsGenetic associationDiseaseAlleleMendelian inheritanceQuantitative trait locusPopulationPhenotypeTraitBiobankSingle-nucleotide polymorphismGeneGenotypeGenetic variantsInternal medicineMedicine

Affiliated Institutions

Related Publications

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess , Adam S. Butterworth , Simon G. Thompson

ABSTRACT Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potential...

2013 Genetic Epidemiology 5908 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

The Genotype-Tissue Expression (GTEx) project.

John T. Lonsdale , Jeffrey Thomas , Mike Salvatore +97 more

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

2013 PubMed 9436 citations

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck , Chia‐Yen Chen , Benjamin M. Neale +1 more

Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the ‘no horizontal ple...

2018 Nature Genetics 8490 citations

Publication Info

Year: 2016
Type: article
Volume: 167
Issue: 5
Pages: 1415-1429.e19
Citations: 1351
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1351

OpenAlex

Cite This

APA Style

                            
                                
                                    William J. Astle, 
                                
                                    Heather Elding, 
                                
                                    Tao Jiang
                                
                                et al.
                            
                            (2016). 
                            The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 
                            Cell
                            , 167
                            (5)
                            , 1415-1429.e19.
                            https://doi.org/10.1016/j.cell.2016.10.042
                        

Identifiers

DOI: 10.1016/j.cell.2016.10.042